Abstract: A microseism information collection system based on STM32F407 was designed in order to accurately collect and transmit microseism monitoring data and real-timely monitor case of coal mine rock burst. The system collects microseism signal by sensors and front-end acquisition and control module FPGA, and transmits the signal to master chip STM32F407, meanwhile, STM32F407 sends gain control signal and synchronization control signal to FPGA, so as to real-timely adjust circuit parameters for site needs. The processed microseism signal was transmitted to ground server by Ethernet, and the server can judge the source location according to analysis and display of the microseism signal. The experiment results show that the system has reliable and high performances, and can meet demands of real-time information collection and transmission.