Abstract: In view of problems that current gas desorption research has small sampling range and there is error between desorption model calculation results and measured data, desorption experiments were carried out on coal samples from multiple mines, so as to expand collection range of coal samples. Based on experimental platform for gas desorption of coal particles, time-varying law of coal particles at different adsorption equilibrium pressures, different temperatures and different particle sizes was analyzed by using the control variable method, and the following conclusions were drawn: the greater the adsorption equilibrium pressure, the greater the gas desorption amount; the larger the particle size, the smaller the desorption amount and desorption speed, but after reaching the threshold particle size, the particle size has less effect on the desorption amount and desorption speed; the higher the temperature, the greater the gas desorption amount; the desorption amount gradually increases and the gas desorption speed gradually decreases with the increase of time.The experimental study on desorption of coal samples under different geological conditions has improved applicability of gas desorption model, and further verified influence of temperature, particle size and other main control factors on gas desorption rule.