Abstract: In view of problem that traditional vector control method is difficult to carry out active heat management for explosion-proof frequency converter, a low loss control method for explosion-proof frequency converter based on model predictive control was proposed. Heat loss model of the explosion-proof converter was established, and conduction loss and switching loss of power devices were deduced and analyzed, and pointed out that the key of low loss control is to reduce the switching frequency. Based on framework of model prediction control system, high-precision prediction model suitable for low-loss control requirements of explosion-proof converter was designed, and then rolling optimization calculation was completed based on value function considering loss characteristics. The proposed method is analyzed and verified based on 1 140 V/2 MW explosion-proof frequency conversion test prototype, the results show that the method can realize multi-objective optimization problem of explosion-proof frequency converter under constraint condition, and rationally allocate multiple optimization objective weight coefficients, and effectively reduce the overall loss of the system under the condition of satisfying dynamic and steady-state performance requirements of explosion-proof frequency converter.