Abstract: In view of problem that existing mine grouting system cannot protect pipeline real-timely when pressure is too large, the paper proposed design scheme of overpressure protection system for long-distance grouting pipeline based on PLC. The system takes Omron PLC as control center, uses pressure transmitter to collect real-time pressure value of current pipeline. If the pressure overruns and continues 50 s, the slurry pump stops working to achieve emergency stop. Monitoring system on PC receives real-time pressure and flow values from PLC control system and displays them, so as to achieve monitoring of pressure and flow of main grouting pipeline. Industrial test results show that the overpressure protection system works well, and can meet the demands of overpressure protection of mine grouting system.