Abstract: For problems of complex wiring and high cost of wired data transmission mode of traditional temperature detection system, a wireless temperature detection system was designed based on AT89S51 microcontroller, digital temperature sensor DS18B20 and radio frequency transceiver chip nRF905. The system uses DS18B20 for site temperature measurement, completes wireless data transmission by nRF905, and uses AT89S51 for data processing as well as communication with the computer, which achieves multipoint temperature acquisition and long-distance wireless transmission.