Abstract: In view of problem that it need make protocol conversion for adaptation between IEEE802.15.4 and IPv6 when interconnecting mine WSN with 6LoWPAN technology and Internet, the paper proposed a design scheme of IPv4/IPv6 adaptation layer. The scheme uses design idea of division and integration: firstly making design for IPv4 adaptation layer and IPv6 adaptation layer separately, then integrating IPv4 adaptation layer and IPv6 adaptation layer through analyzing the two designs to make IPv4 adaptation layer and IPv6 adaptation layer become optional IPv4/IPv6 adaptation layer. The paper also introduced application implementation of the scheme in gateway of mine personnel location system. The next research emphasis is to find corresponding hardware to support the scheme applied in practice.