Abstract: The paper introduced a design scheme of data uploading software for personnel location based on VB6.0. The software acquires data from database of personnel location system and generates text data according to some form rules, so as to get initialization file and real-time data file for interfaces. The software runs after setting configuration file according to some requirements without installation and maintenance, and uses an encryption method based on time and disk sequence number to assure the maximum benefit of developer. Application showed the software has simple operation and reliable running.