Abstract: For normal use of water supply rescue system, the paper designed a monitoring system of mine water supply pipeline. The system can real-timely monitor parameters of pipeline flow, pressure, temperature and others through sensor, and transmit collected data to monitoring substation. Meanwhile, the monitoring substation can real-timely upload monitoring data to main and standby monitoring computer which makes analysis of received data to determine whether pipeline is abnormal, and saves the finished form data, forms reports and curve analysis for decision makers. The practical application showed that the system is stable in running and reliable in operation and can reflect true underground hydrology, which provides reliable basis for water supply rescue system.