Abstract: The paper introduced a design scheme of distributed networked control system based on the modulation mechanism of neuroendocrine-immune network ,and discussed the operating mechanisms and control functions of various entities which exist in execution level,coordination level,and management level of the system in details.Then it put forward an optimized control structure and optimized the control parameters through the genetic algorithm.The simulation results showed that the optimized control structure can eliminate control error quickly and stably.Therefore,the feasibility of the networked control system is ensured in practical application.