Abstract: In view of present situation of frequent activities of deep ground pressure in Lead-zinc Mine of Xitieshan, the paper proposed a design scheme of real-time monitoring system for microseism based on LabVIEW. The system uses three-component geophone to detect microseism signal and transmit the signal to industrial computer and LabVIEW software platform to make process through preamplifier circuit, filtering circuit, NI CRIO-9014 and NI 9201, so as to realize real-time monitoring and location function for microseism. The actual application showed that real-time performance and accuracy of the system meet with design requirements and the system has certain feasibility.