Abstract: The paper analyzed characteristics of RS485 communication protocol adopted extensively at present in monitoring and control system for mine safety in production.Aiming at this protocol’s limitation,it put forward CAN communication protocol which is better than RS485.And on the basis of original monitoring and control system for mine safety in production,the paper put forward a design scheme of(monitoring) and control system for mine safety in production adopting CAN communication protocol,and(expounded) the application of CAN communication protocol.