Abstract: Aiming at problem that communication nodes and perception nodes based on different wireless communication protocols could not achieve intelligent connection in current mine cyber-physical system (CPS), a multi-mode communication node was constructed by integrating multiple communication modules on the communication node, and an intelligent multi-node communication strategy of mine CPS based on progressive neural network was proposed. The progressive neural network is used to control the multi-mode communication node to switch working mode accurately and realize independent establishment of heterogeneous wireless communication network. The asynchronous advantage actor-critic algorithm is used to perform deep training on the progressive neural network to improve convergence speed and training accuracy of the progressive neural network. The experimental results show that the strategy can realize accurate and reliable communication between multi-mode communication nodes and multi-class perception nodes.