Abstract: In view of problem that present mine ventilation system control had not been considered from overall perspective of ventilation system, a grading control method of mine ventilation system was proposed based on structure of mine ventilation system and air volume distribution characteristics. Firstly, deviation value of ventilation condition parameters of each ventilation location is obtained by comparing real-time acquisition value and safety setting value of the ventilation condition parameters. Then the deviation value is online adjusted and modified by use of automatic correction controller, which is transmitted to PID controller to obtain ventilation condition adjustment parameters. At last, frequency converter of main fan power supply module, electric air door and air-filled air bag at the end of compressed air pipeline are respectively controlled by intelligent control module according to the ventilation condition adjustment parameters, so as to realize dynamic adjustment of air volume at three levels, which are air volume control of whole mine, air volume control of mining area and air volume control of working face. The control method meets requirements of sequential, systematic and coherent regulation of air volume in ventilation system.